MS-driven molecular assembly
How do you incorporate MS data into protein modeling and docking activities? We develop innovative methods and computational strategies to advance MS-driven structural biology of protein complexes.
New reagents for protein mass spectrometry
We have a program designed to identify and characterize new reagents for protein mass spectrometry. We focus particularly on novel enzymes for bottom-up and middle-down proteomics methods applied to labeled and crosslinked proteins.
Structural MS of mitotic regulation
We are interested in mechanisms of microtubule plus-end engagement and the integration of signalling complexes on the microtubule lattice. Our work supports a wider program in antimitotic drug development.
Structural MS of host-pathogen interactions
Understanding mechanisms of iron-uptake by pathogenic bacteria is essential for the development of vaccines targeting childhood infections (e.g. Neisseria meningitidis). A collaboration with microbiologist Dr. Tony Schryvers (University of Calgary) and structural biologist Dr. Trevor Moraes (University of Toronto).
Structural MS of DNA damage repair
Building an accurate structural model of essential repair machinery is central to understanding mechanisms of repair and developiong new anticancer strategies. A collaboration with cell biologist Dr. Susan Lees-Miller (University of Calgary).
Dr. David C. Schriemer
Staff, SAMS Centre
Research associate at Pasteur Institute (France)
Laboratory Scientist at Calgary Laboratory Services
Associate Scientist at Gilead Sciences